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About Fucoidan Research

For thousands of years and in many cultures, algae or seaweed has been consumed both as a food and as medicine. It has nutrients and health benefits that are very different from the vegetation on land. Fucoidan is a highly bioactive polysaccharide found mainly in various species of brown algae and brown seaweed. In nature, fucoidan plays a very important role protecting the sporophyll (the reproductive portion of the algae) from bacterial and viral infection and it also helps maintain the overall health of the sporophyll. Once fucoidan is removed or washed off of the sporophyll, the sporophyll loses its reproductive abilities and dies very quickly. This demonstrates the power and importance of fucoidan.

Fucoidan activates mechanism to induce apoptosis in tumor cells

Apoptosis is a programmed-cell-death mechanism that removes cells during development, eliminates potentially cancerous and virus-infected cells, and maintains balance in the body. Many cells in the human body have the built-in ability to undergo apoptosis. When cells become abnormal, such as those with DNA damage, viral infections, or those that are pre-cancerous, they will undergo apoptosis. As a result, the threat to the rest of the organism is removed.

Apoptosis plays an essential role in the development and maintenance of a healthy immune system. Billions of cells go through apoptosis every hour in a healthy human. Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die. Fucoidan helps to battle cancer by promCaspase-dependent and caspase-independent induction of apoptosis in breast cancer by fucoidan via the PI3K/AKT/GSK3β pathway in vivo and in vitro.oting apoptosis, which breaks down cancer cells, while leaving normal cells alone.

Research Articles:

Caspase-dependent and caspase-independent induction of apoptosis in breast cancer by fucoidan via the PI3K/AKT/GSK3β pathway in vivo and in vitro.™

Xue M1, Ji X2, Xue C3, Liang H4, Ge Y1, He X5, Zhang L6, Bian K7, Zhang L7.

PMID: 28810530

https://www.ncbi.nlm.nih.gov/pubmed/?term=28810530

Efficacy of Low-Molecular-Weight Fucoidan as a Supplemental Therapy in Metastatic Colorectal Cancer Patients: A Double-Blind Randomized Controlled Trial

Tsai HL1,2, Tai CJ3,4, Huang CW5,6, Chang FR7, Wang JY8,9,10,11,12,13.

PMID: 28430159

https://www.ncbi.nlm.nih.gov/pubmed/?term=28430159

Fucoidan Suppresses the Growth of Human Acute Promyelocytic Leukemia Cells In Vitro and In Vivo.

Atashrazm F1, Lowenthal RM1, Woods GM1,2, Holloway AF2, Karpiniec SS3, Dickinson JL1.

PMID: 26241708

https://www.ncbi.nlm.nih.gov/pubmed/?term=26241708

Fucoidan, a major component of brown seaweed, prohibits the growth of human cancer cell lines in vitro.

Fukahori S, Yano H, Akiba J, Ogasawara S, Momosaki S, Sanada S, Kuratomi K, Ishizaki Y, Moriya F, Yagi M, Kojiro M.

PMID: 21479446

https://www.ncbi.nlm.nih.gov/pubmed/21479446

Fucoidan extract induces apoptosis in MCF-7 cells via a mechanism involving the ROS-dependent JNK activation and mitochondria-mediated pathways.

Zhang Z, Teruya K, Eto H, Shirahata S.

PMID:22096572

https://www.ncbi.nlm.nih.gov/pubmed/22096572

Fucoidan induces apoptosis of human HS-sultan cells accompanied by activation of caspase-3 and down-regulation of ERK pathways.

Aisa Y, Miyakawa Y, Nakazato T, Shibata H, Saito K, Ikeda Y, Kizaki M.

PMID:15609279

https://www.ncbi.nlm.nih.gov/pubmed/15609279

The anticancer effect of fucoidan in PC-3 prostate cancer cells.

Boo HJ, Hong JY, Kim SC, Kang JI, Kim MK, Kim EJ, Hyun JW, Koh YS, Yoo ES, Kwon JM, Kang HK.

PMID:23966032

https://www.ncbi.nlm.nih.gov/pubmed/23966032

The mechanism of fucoidan-induced apoptosis in leukemic cells: involvement of ERK1/2, JNK, glutathione, and nitric oxide.

Jin JO1, Song MG, Kim YN, Park JI, Kwak JY.

PMID: 20572161

https://www.ncbi.nlm.nih.gov/pubmed/20572161

Effect of Sulfated Polysaccharides from Brown Algae on Apoptosis of Human Peripheral Blood Lymphocytes.

Gazha AK, Zaporozhets TS, Kuznetsova TA, Zvyaguintseva TN, Besednova NN.

PMID:26459478

https://www.ncbi.nlm.nih.gov/pubmed/26459478

Fucoidan present in brown algae induces apoptosis of human colon cancer cells.

Kim EJ, Park SY, Lee JY, Park JH.

PMID: 20727207

https://www.ncbi.nlm.nih.gov/pubmed/20727207

Fucoidan from Undaria pinnatifida induces apoptosis in A549 human lung carcinoma cells.

Boo HJ, Hyun JH, Kim SC, Kang JI, Kim MK, Kim SY, Cho H, Yoo ES, Kang HK.

PMID:21452391 

https://www.ncbi.nlm.nih.gov/pubmed/21452391

Fucoidan suppresses angiogenesis and stops cancer cell metastasis

Cancer is difficult to cure because of its ability to break away from the original tumor and spread through the other parts of the body through the bloodstream or lymph system. This spread of cancer to a new part of the body is called metastasis. In order to effectively treat cancer and prevent it from reoccurring, it is crucial to stop cancer cell metastasis. Tumor growth is highly dependent on an adequate supply of oxygen and nutrients. For the metastatic spread of cancer tissue, growth of the vascular network is important. This development of new blood vessels is called angiogenesis and it plays an essential role in the formation of a new vascular network to supply nutrients and oxygen.

Tumor cells secrete and release angiogenic activators into the surrounding tissues and thus promote the formation of new blood vessels. Researchers have proven that fucoidan binds and neutralize these angiogenic activators, hence inhibits angiogenesis. Fucoidan suppresses the growth of new blood vessels around tumors, thus inhibiting the growth of cancer.

Research Articles:

A fucoidan from Nemacystus decipiens disrupts angiogenesis through targeting bone morphogenetic protein 4.

Wang W1, Chen H1, Zhang L1, Qin Y1, Cong Q1, Wang P1, Ding K2.

PMID: 27083822

https://www.ncbi.nlm.nih.gov/pubmed/?term=27083822

Oversulfation of fucoidan enhances its anti-angiogenic and antitumor activities.

Koyanagi S1, Tanigawa N, Nakagawa H, Soeda S, Shimeno H.

PMID: 12504793

https://www.ncbi.nlm.nih.gov/pubmed/?term=12504793

Fucoidan inhibits angiogenesis induced by multiple myeloma cells.

Liu F1, Luo G1, Xiao Q1, Chen L1, Luo X1, Lv J1, Chen L2.

PMID: 27498597

https://www.ncbi.nlm.nih.gov/pubmed/?term=27498597

Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo.

Xue M, Ge Y, Zhang J, Wang Q, Hou L, Liu Y, Sun L, Li Q.

PMID:22916270

https://www.ncbi.nlm.nih.gov/pubmed/?term=22916270

Neoangiogenesis induced by progenitor endothelial cells: effect of fucoidan from marine algae.

Boisson-Vidal C, Zemani F, Caligiuri G, Galy-Fauroux I, Colliec-Jouault S, Helley D, Fischer AM.

PMID:17266549

https://www.ncbi.nlm.nih.gov/pubmed/?term=17266549

Effects of middle molecular weight fucoidans on in vitro and ex vivo angiogenesis of endothelial cells.

Matsubara K, Xue C, Zhao X, Mori M, Sugawara T, Hirata T.

PMID:15754034

https://www.ncbi.nlm.nih.gov/pubmed/?term=15754034

Protamine enhances uptake of cationic liposomes in angiogenic microvessels.

Eichhorn ME, Strieth S, Krasnici S, Sauer B, Teifel M, Michaelis U, Naujoks K, Dellian M.

PMID:15516834

https://www.ncbi.nlm.nih.gov/pubmed/?term=15516834

Antitumor activity of fucoidan in anaplastic thyroid cancer via apoptosis and anti-angiogenesis.

Shen HY, Li LZ, Xue KC, Hu DD, Gao YJ.

PMID:28447753

https://www.ncbi.nlm.nih.gov/pubmed/28447753

Anti-tumor and anti-angiogenic effects of Fucoidan on prostate cancer: possible JAK-STAT3 pathway.

Rui X, Pan HF, Shao SL, Xu XM.

PMID:28764703

https://www.ncbi.nlm.nih.gov/pubmed/28764703

Comparison of the effects of marchantin C and fucoidan on sFlt-1 and angiogenesis in glioma microenvironment.

Lv Y, Song Q, Shao Q, Gao W, Mao H, Lou H, Qu X, Li X.

PMID:22420666

https://www.ncbi.nlm.nih.gov/pubmed/22420666

Fucoidan boosts the immune system and helps relieve cancer treatment side effects

Fucoidan is also widely known for its ability to help relieve side effects associated with chemotherapy. Research has proven that fucoidan significantly reduces patients’ fatigue level during chemotherapy. As a result, patients can endure more sessions of chemotherapy treatments and at higher doses. In addition, fucoidan helps patients to be stronger physically and mentally, resulting in better quality of life, both during and after chemotherapy treatment.

Research Articles:

Fucoidan can function as an adjuvant in vivo to enhance dendritic cell maturation and function and promote antigen-specific T cell immune responses.

Jin JO1, Zhang W1, Du JY1, Wong KW1, Oda T2, Yu Q3.

PMID:24911024

https://www.ncbi.nlm.nih.gov/pubmed/?term=24911024

Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer.

Ikeguchi M1, Yamamoto M, Arai Y, Maeta Y, Ashida K, Katano K, Miki Y, Kimura T.

PMID: 22866084

https://www.ncbi.nlm.nih.gov/pubmed/?term=22866084

Radioprotective effects of fucoidan in mice treated with total body irradiation.

Lee J1, Kim J, Moon C, Kim SH, Hyun JW, Park JW, Shin T.

PMID: 18683851

https://www.ncbi.nlm.nih.gov/pubmed/?term=18683851

Fucoidan extract enhances the anti-cancer activity of chemotherapeutic agents in MDA-MB-231 and MCF-7 breast cancer cells.

Zhang Z, Teruya K, Yoshida T, Eto H, Shirahata S.

PMID:23303302

https://www.ncbi.nlm.nih.gov/pubmed/23303302

Fucoidin enhances dendritic cell-mediated T-cell cytotoxicity against NY-ESO-1 expressing human cancer cells.

Hu Y, Cheng SC, Chan KT, Ke Y, Xue B, Sin FW, Zeng C, Xie Y.

PMID:20067767

https://www.ncbi.nlm.nih.gov/pubmed/20067767

A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds.

Cumashi A, Ushakova NA, Preobrazhenskaya ME, D’Incecco A, Piccoli A, Totani L, Tinari N, Morozevich GE, Berman AE, Bilan MI, Usov AI,

PMID:17296677

https://www.ncbi.nlm.nih.gov/pubmed/17296677

Uptake of serum-opsonized Francisella tularensis by macrophages can be mediated by class A scavenger receptors.

Pierini LM.

PMID:16882038

https://www.ncbi.nlm.nih.gov/pubmed/?term=16882038

Sulfated polysaccharides derived from dietary seaweeds increase the esterase activity of a lymphocyte tryptase, granzyme A.

Hirayasu H1, Yoshikawa Y, Tsuzuki S, Fushiki T.

PMID:16521710

https://www.ncbi.nlm.nih.gov/pubmed/?term=16521710

Immunomodulating activity of arabinogalactan and fucoidan in vitro.

Choi EM, Kim AJ, Kim YO, Hwang JK.

PMID:16379554

https://www.ncbi.nlm.nih.gov/pubmed/?term=16379554

The immunostimulatory activity of CpG oligonucleotides on microglial N9 cells is affected by a polyguanosine motif.

Zhang Z, Guo K, Schluesener HJ.

PMID: 15748945

https://www.ncbi.nlm.nih.gov/pubmed/?term=15748945

For more researches, please click:

https://www.ncbi.nlm.nih.gov/pubmed/?term=fucoidan+cancer

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  • 100% natural
  • Health Canada approved
  • High fucoidan content
  • No known side effects or adverse reactions
$238 /bottleFree shipping in Canada

Canada FUCOIDAN

  • 100% natural
  • Health Canada approved
  • High fucoidan content
  • No known side effects or adverse reactions
$238 /bottleFree shipping in Canada